Aging is a complicated process with multiple modulations occurring at many levels, from the molecular to the cells. Ginseng, an ancient Chinese herb widely used in Eastern medicine, has been studied for its anti-aging properties., and has been shown to have beneficial effects with regards to anti-inflammation, anti-oxidation, cardiovascular regulation, neurological improvement, anti-tumor, skin protection and immune modulation.
American ginseng is a light tan, gnarled root that often looks like a human body with stringy shoots for arms and legs. Native Americans used the root as a stimulant and to treat headaches, fever, indigestion, and infertility. Ginseng remains one of the most popular herbs in the United States.
Panax ginseng is a traditional herbal medicine that has been used therapeutically for more than 2000 years. It is the most valuable of all medicinal plants, especially in Korea, China, and Japan. The name panax means 'all healing,' and has possibly stemmed from traditional belief that the various properties of ginseng can heal all aspects of the illness encountered by the human body (i.e., it acts as a panacea for the human body) ... The active constituent ginsenosides play a vital role in the medicinal effects of ginseng. Ginsenosides exhibit their vast range of activities on CVD through the inhibition of ROS production, stimulation of NO production, improvement in blood circulation, enhancement of vasomotor tone, and regulation of the lipid profile.
Ginseng effectively regulates the immune response and the hormonal changes due to stress, thus maintaining homeostasis. In addition to suppressing the occurrence of psychological diseases such as anxiety and depression, ginseng also prevents stress-associated physiological diseases ... Ginseng provides a potential approach to regaining homeostasis after abnormal physiological changes caused by the stress of everyday life. The efficacy of this preparation has been demonstrated in various experiments conducted using human cells and animal models.
The molecular mechanisms of the neuroprotective effects of ginseng in Alzheimer’s disease (AD) including β-amyloid (Aβ) formation, tau hyperphosphorylation and oxidative stress, major depression, stroke, Parkinson’s disease and multiple sclerosis are presented. It is hoped that this discussion will stimulate more studies on the use of ginseng in neurological disorders.